Endocrine Abstracts

Background: Many testosterone (T) formulations are now available for treating male hypogonadism. Intramuscular injectable T esters and transdermal T gel are the most commonly used in clinical practice. Transdermal T gel is often preferred by patients due to ease of use and reduced fluctuations in serum T compared to injectable esters. A daily dosage of 20 mg – 80 mg mimicking circadian profile is recommended to adequately treat hypogonadal men.Aim: ...

Background: Hypovitaminosis D represents at present a worldwide public health problem. Recent studies have demonstrated the pleiotropic effects of vitamin D, in addition to its known actions on calcium-phosphorus metabolism. Among the several non-skeletal effects, a potential anti-inflammatory and immunomodulatory action has been suggested. Vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and deregulation of the immune...

Aim: To assess the relation between questionnaires of androgenic function (AMS and IIEF-EF scores) and sex hormones (DHT, estradiol and total and free testosterone) in men attending an outpatient clinic for endocrine and reproductive disorders.Methods: We retrospectively reviewed all data entered in the electronic database of the Münster Center of Reproductive Medicine and Andrology (CeRA) Androbase from patients visited between January 2015 and Oct...

Background: The FSHB –211 G > T single nucleotide polymorphism (SNP) is known to affect pituitary FSH output by reducing the transcriptional activity of FSHB. Identifying the response of the pituitary to exogenous GnRH stimulation in subjects with FSHB -211 G > T SNP could provide useful information concerning the mechanisms regulating FSH synthesis and release.Objectives: This study aimed to assess the pituitary...

Background: Varicocele repair is often suggested to improve reproductive outcomes, but there is no clear indications on which subjects are more likely to benefit from treatment. We assessed spermatogenetic and endocrine function of the testis in a population of young subjects with a 12-month follow-up following percutaneous treatment.Methods: We retrospectively reviewed data from 77 young patients (mean age 23.3 years, range 18–35) followed in our c...